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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DNASE1L1 All Species: 1.52
Human Site: S279 Identified Species: 3.7
UniProt: P49184 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.33
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49184 NP_001009932.1 302 33893 S279 L K L S Q A H S V Q P L S L T
Chimpanzee Pan troglodytes XP_001174037 305 35527 K280 D H F P V E F K L Q S S R A F
Rhesus Macaque Macaca mulatta XP_001097104 305 35444 K280 D H F P V E F K L Q S S R A F
Dog Lupus familis XP_549370 295 33342 S272 Y P V E V E L S R A A P R V Q
Cat Felis silvestris
Mouse Mus musculus Q9D7J6 314 35586 T292 E V E L S Q A T P L S I P P H
Rat Rattus norvegicus Q2QDE7 312 35163 A275 F Q L T E E E A L R V S D H Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506333 315 35674 F288 G P G S A F P F H F E K A Y K
Chicken Gallus gallus Q9YGI5 282 31382 R260 N N F Q E T L R I Q N K D A L
Frog Xenopus laevis NP_001090620 297 33927 L272 L N G Q N P L L P S C T L L A
Zebra Danio Brachydanio rerio NP_001002403 292 34004 A267 F N L S E E E A L E V S D H F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 40 40.3 80.1 N.A. 66.5 66.9 N.A. 35.8 36 42.7 43 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 61.6 61.3 85 N.A. 75.4 75.9 N.A. 53.9 54.9 61.9 61.5 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 6.6 6.6 6.6 N.A. 0 6.6 N.A. 6.6 6.6 13.3 13.3 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 13.3 13.3 20 N.A. 13.3 46.6 N.A. 13.3 20 13.3 40 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 10 10 10 20 0 10 10 0 10 30 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % C
% Asp: 20 0 0 0 0 0 0 0 0 0 0 0 30 0 0 % D
% Glu: 10 0 10 10 30 50 20 0 0 10 10 0 0 0 0 % E
% Phe: 20 0 30 0 0 10 20 10 0 10 0 0 0 0 30 % F
% Gly: 10 0 20 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 20 0 0 0 0 10 0 10 0 0 0 0 20 10 % H
% Ile: 0 0 0 0 0 0 0 0 10 0 0 10 0 0 0 % I
% Lys: 0 10 0 0 0 0 0 20 0 0 0 20 0 0 10 % K
% Leu: 20 0 30 10 0 0 30 10 40 10 0 10 10 20 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 10 30 0 0 10 0 0 0 0 0 10 0 0 0 0 % N
% Pro: 0 20 0 20 0 10 10 0 20 0 10 10 10 10 0 % P
% Gln: 0 10 0 20 10 10 0 0 0 40 0 0 0 0 10 % Q
% Arg: 0 0 0 0 0 0 0 10 10 10 0 0 30 0 0 % R
% Ser: 0 0 0 30 10 0 0 20 0 10 30 40 10 0 0 % S
% Thr: 0 0 0 10 0 10 0 10 0 0 0 10 0 0 10 % T
% Val: 0 10 10 0 30 0 0 0 10 0 20 0 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 10 0 0 0 0 0 0 0 0 0 0 0 0 10 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _